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Oncology immunotherapy mechanisms and efficacy
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Module 1
Foundations of Cancer Immunology
1
Innate vs. Adaptive Immunity: Key Cells
Distinguish between the innate and adaptive immune systems, listing the key cell types involved in each.
2
Antigen Presentation: The Role of Dendritic Cells
Describe the function of antigen-presenting cells (APCs), with a focus on dendritic cells.
3
MHC Class I and II Antigen Presentation
Explain the process of antigen presentation via MHC class I and MHC class II molecules.
4
CD8+ vs. CD4+ T-Cells in Anti-Tumor Immunity
Contrast the roles of CD8+ cytotoxic T-cells and CD4+ helper T-cells in an anti-tumor immune response.
5
B-Cell Function: Antibody Production and APC Role
Describe the function of B-cells in producing antibodies and their role as APCs.
6
T-Cell Activation: The Two-Signal Model
Outline the steps of T-cell activation, including the 'two-signal' model involving the T-cell receptor (TCR) and co-stimulatory molecules.
7
The Cancer-Immunity Cycle: Stages and Interventions
Define the 'Cancer-Immunity Cycle' and identify key stages for therapeutic intervention.
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Antibody-Drug Conjugates (ADCs)