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Oncology immunotherapy mechanisms and efficacy
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Module 3
Antibody-Drug Conjugates (ADCs)
ADC Fundamentals: Antibody, Payload, and Linker
Define the three core components of an Antibody-Drug Conjugate (ADC): the monoclonal antibody, the cytotoxic payload, and the linker.
ADC Mechanism of Action: A Step-by-Step Guide
Describe the step-by-step mechanism of action of an ADC, from target binding and internalization to payload release and cell killing.
3
Target Antigen Selection for ADCs
Analyze the key biological characteristics of an ideal target antigen for an ADC, including expression levels, heterogeneity, and internalization rate.
4
Linker Chemistry in ADCs: Efficacy, Safety, and Bystander Effect
Explain how linker chemistry (cleavable vs. non-cleavable) influences an ADC's efficacy, safety, and potential for a 'bystander effect'.
Enhertu: Antibody-Drug Conjugate Design and Clinical Impact
Using Enhertu (trastuzumab deruxtecan) as an example, analyze how its specific antibody, cleavable linker, and potent payload contribute to its clinical activity.
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