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PCOS: Aetiology, features, management
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Module 8
Genetic and Epigenetic Basis of PCOS
1
From DNA to Protein: The Central Dogma and Gene Expression
Explain the central dogma of molecular biology (DNA to protein) and the concept of gene expression.
2
Genetic Variation and PCOS: Insights from Family Studies
Define genetic variation and explain its role in disease susceptibility, supported by evidence from familial and twin studies in PCOS.
3
GWAS Methodology in PCOS Susceptibility
Outline the methodology of genome-wide association studies (GWAS) and their role in identifying PCOS susceptibility loci.
4
PCOS Genes: Insulin, Androgens & Beyond
Describe key candidate genes associated with PCOS, linking them to pathways like insulin signaling and androgen biosynthesis.
5
Epigenetics: Mechanisms of Gene Regulation
Explain the concept of epigenetics and describe major mechanisms like DNA methylation and histone modification.
6
Epigenetics and PCOS: Unraveling Gene-Environment Interactions
Discuss how epigenetic modifications and gene-environment interactions may contribute to PCOS pathogenesis.
7
PCOS and DOHaD: The Intrauterine Connection
Describe the theory of intrauterine programming and the developmental origins of health and disease (DOHaD) as it applies to PCOS.
Previous module
PCOS: Definition, Diagnosis, and Epidemiology
Next module
Pathophysiology of PCOS: Hyperandrogenism