Reaction Thermodynamics and Kinetics

Calculate the enthalpy change (ΔH) for organic reactions using bond dissociation energies.

Predict the sign of the entropy change (ΔS) for organic reactions based on changes in molecular freedom.

Use Gibbs free energy (ΔG) to predict the spontaneity and equilibrium position of an organic reaction.

Analyze reaction coordinate diagrams to identify the rate-determining step, intermediates, and transition states.

Apply Hammond's postulate to infer transition state structure and predict reaction selectivity.

Correlate experimental kinetic data (e.g., rate laws) with reaction molecularity to support or refute a proposed mechanism.